Lesion-wise analysis included 1075 nPR-WMLs and 39 PRLs. Voxel-wise histogram analysis showed a unimodal histogram for nPR-WMLs and a bimodal histogram for PRLs with a large peak in the hypointense limit. The lesions were divided equally into training and test datasets, and the fifth-percentile (p5)-normalized T1-intensity of each lesion was compared between groups and used for classification prediction. PRLs and nPR-WMLs were segmented, and voxel-wise normalized T1-intensity histograms were analyzed. This study enrolled a cohort of relapsing–remitting ( n = 10) and secondary progressive MS ( n = 10) patients for whom 3 T MRI was available.
We then evaluated the performance of a derived metric as a surrogate for PRLs as potential markers for risk of disease progression. The aim of this study was to compare the intensity profiles of PRLs and non-PRL white-matter lesions (nPR-WMLs) on three-dimensional T1-weighted turbo field echo (3DT1TFE) MRI. Previous studies have identified T1-hypointensity in PRLs. Phase-rim lesions (PRLs) have been proposed as markers of progressive disease but are difficult to identify and quantify. The development of new drugs for the treatment of progressive multiple sclerosis (MS) highlights the need for new prognostic biomarkers.
